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Yukihiko Hara Selected Research

Tea

1/2022Epigallocatechin gallate (EGCG) attenuates severe acute respiratory coronavirus disease 2 (SARS-CoV-2) infection by blocking the interaction of SARS-CoV-2 spike protein receptor-binding domain to human angiotensin-converting enzyme 2.
6/2020Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers.
1/2013Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells.
7/2012A six-month crossover chemoprevention clinical trial of tea in smokers and non-smokers: methodological issues in a feasibility study.
8/2011Tea catechins and their applications as supplements and pharmaceutics.
3/2011Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
10/2010The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.
6/2010Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.
5/2010(-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells.
1/2010Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor.
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Yukihiko Hara Research Topics

Disease

23Neoplasms (Cancer)
06/2020 - 01/2002
12Carcinogenesis
03/2011 - 03/2002
5Body Weight (Weight, Body)
09/2021 - 05/2007
4Colonic Neoplasms (Colon Cancer)
09/2005 - 03/2002
3Infections
01/2022 - 02/2006
3Colorectal Neoplasms (Colorectal Cancer)
05/2010 - 09/2005
3Hepatocellular Carcinoma (Hepatoma)
10/2009 - 04/2008
3Lung Neoplasms (Lung Cancer)
06/2009 - 01/2006
3Adenoma (Adenomas)
06/2009 - 01/2006
2Breast Neoplasms (Breast Cancer)
05/2009 - 07/2007
2Neoplasm Metastasis (Metastasis)
05/2009 - 06/2008
1COVID-19
01/2022
1Warts (Wart)
06/2020
1Cardiovascular Diseases (Cardiovascular Disease)
01/2018
1Leukemia
01/2013
1Mouth Neoplasms (Oral Cancer)
07/2012
1Condylomata Acuminata (Genital Wart)
08/2011
1Fatty Liver
03/2011
1Obesity
03/2011
1Liver Cell Adenoma (Hepatocellular Adenoma)
03/2011
1Adenocarcinoma
10/2010
1Prostatic Neoplasms (Prostate Cancer)
10/2010
1Hypoxia (Hypoxemia)
05/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2010
1Fibrosis (Cirrhosis)
12/2009
1Liver Cirrhosis (Hepatic Cirrhosis)
12/2009
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
10/2009
1Alzheimer Disease (Alzheimer's Disease)
09/2008
1Cognitive Dysfunction
09/2008
1Colitis
05/2008
1Inflammation (Inflammations)
05/2008
1Liver Neoplasms (Liver Cancer)
04/2008
1Carcinoma (Carcinomatosis)
12/2007

Drug/Important Bio-Agent (IBA)

33TeaIBA
01/2022 - 02/2002
16epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2022 - 02/2002
11PolyphenolsIBA
01/2022 - 12/2002
10Catechin (Z 7300)IBA
06/2020 - 02/2002
9polyphenon EIBA
10/2010 - 01/2003
5Proteins (Proteins, Gene)FDA Link
03/2011 - 09/2005
4Insulin-Like PeptidesIBA
03/2011 - 04/2008
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2010 - 12/2007
4polyphenon BIBA
10/2008 - 10/2006
3Drinking WaterIBA
03/2011 - 01/2006
3IGF Type 1 Receptor (IGF 1 Receptor)IBA
03/2011 - 04/2008
3AntioxidantsIBA
06/2010 - 08/2004
3CarcinogensIBA
06/2010 - 11/2003
3tyrosine receptor (receptor, tyrosine)IBA
05/2010 - 10/2009
3Phosphotransferases (Kinase)IBA
05/2010 - 10/2009
3Insulin (Novolin)FDA Link
01/2010 - 09/2005
2EnzymesIBA
01/2022 - 10/2008
2Indicators and Reagents (Reagents)IBA
01/2013 - 03/2002
2Benzo(a)pyreneIBA
06/2010 - 01/2006
2Neuregulin-1 (Neuregulin 1)IBA
05/2010 - 05/2009
2Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
05/2010 - 10/2009
2TOR Serine-Threonine KinasesIBA
01/2010 - 01/2006
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2009 - 04/2008
2gallocatechol (epigallocatechin)IBA
05/2009 - 09/2008
2AzoxymethaneIBA
05/2008 - 03/2002
2anthraceneIBA
12/2007 - 10/2006
1PhytochemicalsIBA
01/2022
1Angiotensin-Converting Enzyme 2IBA
01/2022
1Angiotensin Receptors (Angiotensin II Receptor)IBA
01/2022
1SARS-CoV-2 spike proteinIBA
01/2022
1Guanosine Triphosphate (GTP)IBA
09/2021
1Blood Glucose (Blood Sugar)IBA
09/2021
1Peptidylprolyl Isomerase (Prolyl Isomerase)IBA
01/2018
1Biomarkers (Surrogate Marker)IBA
07/2012
1Diethylnitrosamine (N-Nitrosodiethylamine)IBA
03/2011
1AMP-Activated Protein KinasesIBA
03/2011
1vineatrolIBA
10/2010
1sphingosine kinaseIBA
10/2010
1ResveratrolIBA
10/2010
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
10/2010
1LycopeneIBA
06/2010
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
05/2010
1Epidermal Growth Factor (EGF)IBA
05/2010
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2010
1Insulin-Like Growth Factor II (Somatomedin A)IBA
05/2010
1Focal Adhesion Protein-Tyrosine KinasesIBA
01/2010
1Mitogen-Activated Protein KinasesIBA
01/2010
1Platelet-Derived Growth FactorIBA
12/2009
1Carbon Tetrachloride (Tetrachloromethane)IBA
12/2009
1Hydroxyproline (4 Hydroxyproline)IBA
12/2009
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
12/2009
1CaspasesIBA
10/2009
1Imatinib Mesylate (Gleevec)FDA Link
10/2009
1Tyrosine Kinase InhibitorsIBA
10/2009
1AerosolsIBA
06/2009
1Complex MixturesIBA
06/2009
1histidine-rich proteinsIBA
05/2009
1XenobioticsIBA
10/2008
1epicatechin gallateIBA
09/2008
1Amyloid beta-PeptidesIBA
09/2008
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
06/2008
1sodium sulfate (sodium bisulfate)FDA LinkGeneric
05/2008
1Dextrans (Dextran)FDA Link
05/2008
1NF-kappa B (NF-kB)IBA
12/2007

Therapy/Procedure

7Chemoprevention
03/2011 - 09/2005
4Therapeutics
01/2010 - 11/2003
2Intraperitoneal Injections
06/2010 - 05/2008